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Frequently asked questions
What does AVPCD 2.0 contain?
Antiviral potency values (IC50, EC50, IC90, EC90 and ED50) of compounds from plants, each tied to the virus, the assay and the paper it was read from. Reference drugs, semisynthetic derivatives, single-concentration % inhibition rows and plant-virus assays are left out.
How were the records made?
Four curators extracted the records from the papers assigned to them, with AI-tool assistance, and reviewed them. This description comes from the curators and has not been independently verified. The outputs of the AI tools were not kept.
How are structures assigned to compounds?
By looking up the compound name as printed in the paper in PubChem, NCI CACTUS, COCONUT, LOTUS and NPASS. The matches were not checked by hand. Names that no database knows, and labels that exist only in one paper (such as “Compound 7”), have no structure. Matches that were only approximate were rejected.
Why does a record have no plant species?
The paper may not name a plant, for example for a purchased standard. For some such records a plant was found only for the compound in an external database. That shows where the compound occurs in general, not the plant of the assay sample; the record says which case applies.
Why is the value in nM empty?
Values printed in mass units (such as µg/mL) are converted to nM only when the molecular weight of the matched structure is known. The value as printed is always kept.
What does “Unit to check” mean?
On three papers the recorded unit may be 1,000 times away from the unit in the paper (recorded mg/mL or mM; the paper may say ug/mL or uM). Records on those papers are marked “Unit to check”. Compare them with the paper before use.
Under which licence can I use the records?
The curated records and derived fields are released under the Creative Commons Attribution 4.0 International licence (CC BY 4.0). Please attribute the database when you use them. Only extracted values and identifiers are held, never the text of a paper.
What is not in the database?
NPASS and ChEMBL values (only identifiers were used for comparison), the text of papers, and curator identifiers.